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(floor'' oh ure' a sil)Fluorouracil injection should be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Treatment with fluorouracil injection may cause serious side effects.
Before receiving fluorouracil,
- tell your doctor and pharmacist if you are allergic to fluorouracil or any of the ingredients in fluorouracil injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain chemotherapy medications such as bendamustine (Treanda), busulfan (Myerlan, Busulfex), carmustine (BiCNU, Gliadel Wafer), cyclophosphamide (Cytoxan), chlorambucil (Leukeran), ifosfamide (Ifex), lomustine (CeeNU), melphalan (Alkeran), procarbazine (Mutalane), or temozolomide (Temodar); medications that suppress the immune system such as azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have an infection. Your doctor may not want you to receive fluorouracil injection.
- tell your doctor if you have previously received radiation (x-ray) therapy or treatment with other chemotherapy medications or if you have or have ever had kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breast-feed while you are receiving fluorouracil injection. If you become pregnant while receiving fluorouracil injection, call your doctor. Fluorouracil may harm the fetus.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Fluorouracil may make your skin sensitive to sunlight.
- loss of appetite
- unusual tiredness or weakness
- hair loss
- dry and cracked skin
- vision changes
- eye that are teary or sensitive to light
- redness, pain, swelling, or burning at the site where the injection was given
- sores in the mouth and throat
- swelling, pain, redness, or peeling of skin on the palms and soles of the feet
- fever, chills, sore throat, or other signs of an infection
- difficulty breathing or swallowing
- coughing up or vomiting blood or material that looks like coffee grounds
- unusual bleeding or bruising
- pink, red, or dark brown urine
- red or tarry black bowel movements
- chest pain