Lantus (Insulin Glargine Recombinant)

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Insulin Glargine Recombinant Information

Human Insulin Injection (in' su lin) Humulin R® Humulin N® Humulin 70/30® Humulin 50/50®¶ Humulin R U-500® Myxredlin® Novolin R® Novolin N® Novolin 70/30®

Insulin lispro is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) who need insulin to control their diabetes. In patients with type 1 diabetes, insulin lispro is always used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, insulin lispro may be used with another type of insulin or with oral medication(s) for diabetes. Insulin lispro is a short-acting, manmade version of human insulin. Insulin lispro works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease.Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Human insulin comes as a solution (liquid) and a suspension (liquid with particles that will settle on standing). to be injected subcutaneously (under the skin). Human insulin is usually injected subcutaneously several times a day, and more than one type of insulin may be needed. Your doctor will tell you which type(s) of insulin to use, how much insulin to use, and how often to inject insulin. Follow these directions carefully. Do not use more or less insulin or use it more often than prescribed by your doctor. Human insulin (Myxredlin, Humulin R U-100, Novolin R) solution may also be injected intravenously (into a vein) by a doctor or nurse in a healthcare setting. A doctor or nurse will carefully monitor you for side effects. Human insulin controls high blood sugar but does not cure diabetes. Continue to use human insulin even if you feel well. Do not stop using insulin without talking to your doctor. Do not switch to another brand or type of insulin or change the dose of any type of insulin you use without talking to your doctor. Human insulin comes in vials, prefilled disposable dosing devices, and cartridges. The cartridges are designed to be placed in dosing pens. Be sure you know what type of container your insulin comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication. Make sure that the name and letter on your insulin are exactly what your doctor prescribed. If your human insulin comes in vials, you will need to use syringes to inject your dose. Be sure that you know whether your human insulin is U-100 or U-500 and always use a syringe marked for that type of insulin. Always use the same brand and model of needle and syringe. Ask your doctor or pharmacist if you have questions about the type of syringe you should use. Carefully read the manufacturer's instructions to learn how to draw insulin into a syringe and inject your dose. Ask your doctor or pharmacist if you have questions about how to inject your dose. If your human insulin comes in cartridges, you may need to buy an insulin pen separately. Talk to your doctor or pharmacist about the type of pen you should use. Carefully read the instructions that come with your pen, and ask your doctor or pharmacist to show you how to use it. If your human insulin comes in a disposable dosing device, read the instructions that come with the device carefully. Ask your doctor or pharmacist to show you how to use the device. Never reuse needles or syringes and never share needles, syringes, cartridges, or pens. If you are using an insulin pen, always remove the needle right after you inject your dose. Dispose of needles and syringes in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container. Your doctor may tell you to mix two types of insulin in the same syringe. Your doctor will tell you exactly how to draw both types of insulin into the syringe. Follow these directions carefully. Always draw the same type of insulin into the syringe first, and always use the same brand of needles. Never mix more than one type of insulin in a syringe unless you are told to do so by your doctor. Always look at your human insulin before you inject. If you are using a regular human insulin (Humulin R, Novolin R), the insulin should be as clear, colorless, and fluid as water. Do not use this type of insulin if it appears cloudy, thickened, or colored, or if it has solid particles. If you are using an NPH human insulin (Humulin N, Novolin N) or a premixed insulin that contains NPH (Humulin 70/30, Novolin 70/30), the insulin should appear cloudy or milky after you mix it. Do not use these types of insulin if there are clumps in the liquid or if there are solid white particles sticking to the bottom or walls of the bottle. Do not use any type of insulin after the expiration date printed on the bottle has passed. Some types of human insulin must be shaken or rotated to mix before use. Ask your doctor or pharmacist if the type of insulin you are using should be mixed and how you should mix it if necessary. Talk to your doctor or pharmacist about where on your body you should inject human insulin. You can inject your human insulin in the stomach , upper arm, upper leg, or buttocks. Do not inject human insulin into muscles, scars, or moles. Use a different site for each injection, at least 1/2 inch (1.25 centimeters) away from the previous injection site but in the same general area (for example, the thigh). Use all available sites in the same general area before switching to a different area (for example, the upper arm).

Before using insulin, tell your doctor and pharmacist if you are allergic to any type of insulin or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: albuterol (Proair, Proventil, Ventolin, others); alpha blockers such as doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax), and alfuzosin (Uroxatral); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); angiotensin receptor blockers (ARB) such as candesartan (Atacand), irbesartan (Avapro), losartan (Cozaar, in Hyzaar), valsartan (Diovan), others; antidepressants; asparaginase (Elspar); atypical antipsychotics such as aripiprazole (Abilify), clozapine (Clozaril, Fazaclo, Versacloz), olanzapine (Zyprexa, in Symbyax), risperidone (Risperdal), others; beta blockers such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), pindolol, propranolol (Inderal), sotalol (Betapace, Sorine), and timolol (Blocadren); clonidine (Catapres, Kapvay); danazol; diazoxide (Proglycem); disopyramide (Norpace); diuretics ('water pills');fibrates such as fenofibrate (Fenoglide, Tricor, Trilipix), fenofibric acid (Fibricor), gemfibrozil (Lopid); isoniazid (in Rifater, Rifamate); lithium; medications for asthma and colds; medications for mental illness or nausea; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); hormonal contraceptives (birth control pills, patches, rings, injections, or implants); niacin (Niacor, Niaspan, Slo-Niacin); octreotide (Sandostatin);oral medications for diabetes such as pioglitazone (Actos, in Actoplus Met and others) and rosiglitazone (Avandia, in Avandamet and others); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); pentamidine (Nebupent); pentoxifylline (Pentoxil); pramlintide (Symlin); HIV protease inhibitors (PI) such as atazanavir (Reyataz, in Evotaz), darunavir (Prezista), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir; in Kaletra, Viekira Pak, others); quinine; quinidine; salicylate pain relievers such as aspirin; somatropin (Genotropin, Humatrope, Zomacton, others); sulfa antibiotics; terbutaline (Brethine); and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had nerve damage caused by diabetes; heart failure; or heart, adrenal (a small gland near the kidneys), pituitary (a small gland in the brain), thyroid, liver, or kidney disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using human insulin, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are using human insulin. Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are using human insulin. ask your doctor what to do if you get sick, experience unusual stress, plan to travel across time zones, or change your exercise and activity level. These changes can affect your blood sugar and the amount of human insulin you may need. ask your doctor how often you should check your blood sugar. Be aware that hypoglycemia may affect your ability to perform tasks such as driving and ask your doctor if you need to check your blood sugar before driving or operating machinery.

Be sure to follow all dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet, and to eat about the same amounts of the same kinds of food at about the same times each day. Skipping or delaying meals or changing the amount or kind of food you eat can cause problems with your blood sugar control.

Insulin lispro must be injected shortly before or after a meal. If you remember your dose before or shortly after your meal, inject the missed dose right away. If some time has passed since your meal, follow the instructions provided by your doctor or call your doctor to find out whether you should inject the missed dose. Do not inject a double dose to make up for a missed one.

This medication causes changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms. Human insulin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: redness, swelling, and itching at the injection site changes in the feel of your skin, skin thickening (fat build-up), or a little depression in the skin (fat breakdown) weight gain constipation Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: rash and/or itching over the whole body shortness of breath wheezing dizziness blurred vision fast heartbeat sweating difficulty breathing or swallowing weakness muscle cramps abnormal heartbeat large weight gain in a short period of time swelling of the arms, hands, feet, ankles, or lower legs If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Store unopened insulin glulisine vials and pens in the refrigerator away from light. Never allow insulin glulisine to freeze; do not use insulin glulisine that has been frozen and thawed. Opened insulin glulisine vials may be refrigerated or may be stored at room temperature, away from direct sunlight and heat, for up to 28 days. Prefilled pens that have not been used may be refrigerated or may be stored at room temperature, away from direct heat and sunlight, for up to 28 days. Prefilled pens that have been used should not be refrigerated; they should be stored at room temperature for up to 28 days after the first use. Dispose of opened insulin glulisine vials and pens after 28 days. Dispose of unopened, refrigerated insulin glulisine after the expiration date printed on the label has passed. Dispose of any insulin glulisine that has been frozen or exposed to extreme heat. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to insulin detemir. Your doctor will also tell you how to check your response to insulin by measuring your blood sugar levels at home. Follow these instructions carefully. You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency. Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.