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(klor am' bue sil)Chlorambucil can cause a decrease in the number of blood cells in your bone marrow. Your doctor will order laboratory tests before, during, and after your treatment to see if your blood cells are affected by this drug. Keep all appointments with the laboratory. Chlorambucil may increase the risk that you will develop other cancers. Talk to your doctor about this risk. Chlorambucil may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. Chlorambucil may cause permanent infertility (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant, or that you cannot get someone else pregnant. Women who are pregnant should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. If you become pregnant while taking chlorambucil, call your doctor immediately. Chlorambucil may harm the fetus.
Before taking chlorambucil,
- tell your doctor and pharmacist if you are allergic to chlorambucil, other alkylating agents such as bendamustine (Treanda), busulfan (Myleran, Busulfex), carmustine (BiCNU, Gliadel Wafer), cyclophosphamide (Cytoxan), ifosfamide (Ifex), lomustine (CeeNU), melphalan (Alkeran), procarbazine (Mutalane), or temozolomide (Temodar), any other medications, or any of the ingredients in chlorambucil. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you have taken chlorambucil before, but your cancer did not respond to the medication. Your doctor will probably tell you not to take chlorambucil.
- tell your doctor if you have received radiation therapy or other chemotherapy within the last 4 weeks.
- tell your doctor if you have ever had seizures or a head injury.
- tell your doctor if you are breast-feeding.
- do not have any vaccinations without talking to your doctor.
- sores in the mouth and throat
- missed menstrual periods (in girls and women)
- skin rash
- unusual bruising or bleeding
- black, tarry stools
- red urine
- sore throat
- difficulty breathing
- yellowing of the skin or eyes
- pain in the upper right part of the stomach
- dark colored urine
- frequent urination
- unusual lumps or masses