Coartem (Artemether / Lumefantrine)
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Artemether / Lumefantrine Information
(ar tem' e ther) (loo me fan' treen)
Before taking artemether and lumefantrine,
- tell your doctor and pharmacist if you are allergic to artemether and lumefantrine, any other medications, or any of the ingredients in artemether and lumefantrine tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking carbamazepine (Carbatrol, Epitol, Tegretol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); or St. John's wort. Your doctor will probably tell you not to take artemether and lumefantrine if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants including amitriptyline (Elavil), clomipramine (Anafranil), and imipramine (Tofranil); certain antifungals such as fluconazole (Diflucan); itraconazole (Sporanox) and ketoconazole (Nizoral); antimalarials such as mefloquine (Lariam) and quinine (Qualaquin); cisapride (Propulsid) (not available in the U.S.); fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available in the U.S.), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin) (not available in the U.S.), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), and sparfloxacin (Zagam) (not available in the U.S.); macrolide antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S., Ery-tab, Eryc), and telithromycin (Ketek); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), rilpivirine (Edurant, in Complera), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); medications for irregular heartbeat including amiodarone (Cordarone), disopyramide (Norpace), flecainide (Tambocor), procainamide (Procanbid), quinidine, and sotalol (Betapace, Betapace AF, Sorine); and certain medications for mental illness such as pimozide (Orap) and ziprasidone (Geodon). Also tell your doctor or pharmacist if you are taking or have stopped taking halofantrine (Halfan) (not available in the U.S.) within the past month. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with artemether and lumefantrine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you or anyone in your family has had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); or if you have or have ever had a slow, fast, or irregular heartbeat; a recent heart attack; a low level of magnesium or potassium in your blood; kidney, heart, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking artemether and lumefantrine, call your doctor.
- you should know that artemether and lumefantrine may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, and injections). Talk to your doctor about methods of birth control that will work for you while you are taking artemether and lumefantrine.
- muscle or joint pain
- difficulty falling asleep or staying asleep
- loss of appetite
- abnormal or fast heartbeat
- difficulty breathing or swallowing
- swelling of the lips, tongue, face, or throat
- difficulty speaking