Moduretic (Amiloride Hydrochloride / Hydrochlorothiazide)
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Amiloride Hydrochloride / Hydrochlorothiazide Information
(a mil' oh ride) (hye'' droe klor'' oh thye' a zide)
Before taking amiloride and hydrochlorothiazide,
- tell your doctor and pharmacist if you are allergic to amiloride, hydrochlorothiazide, sulfonamide containing medications, any other medications, or any of the ingredients in amiloride and hydrochlorothiazide tablets. Ask your pharmacist or check the patient information for a list of the ingredients.
- do not take amiloride and hydrochlorothiazide if you are taking spironolactone (Aldactone, in Aldactazide), other medications containing triamterene, or potassium supplements or potassium-containing medication supplements.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II receptor antagonists (ARB) such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT), and valsartan (Diovan, in Diovan HCT, Exforge); barbiturates such as phenobarbital and secobarbital (Seconal); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, others), fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol), prednisolone (Prelone, others), prednisone (Rayos), and triamcinolone (Aristocort, Azmacort); corticotropin (ACTH H.P., Acthar Gel); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); insulin and oral medications for diabetes; lithium (Lithobid); medications for high blood pressure; or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin), and naproxen (Aleve, Naprosyn, others); or tacrolimus (Astagraf XL, Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking cholestyramine or colestipol, take them 1 hour before or 4 hours after taking amiloride and hydrochlorothiazide.
- tell your doctor if you have kidney disease. Your doctor may tell you not to take amiloride and hydrochlorothiazide.
- tell your doctor if you have or have ever had diabetes, gout, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking amiloride and hydrochlorothiazide, call your doctor immediately.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking amiloride and hydrochlorothiazide.
- you should know that amiloride and hydrochlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking amiloride and hydrochlorothiazide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.
- upset stomach
- loss of appetite
- stomach pain
- dry mouth; thirst; nausea; vomiting; weakness, tiredness; drowsiness; restlessness; confusion; muscle weakness, pain, or cramps; fast heartbeat and other signs of dehydration and electrolyte imbalance
- slow or irregular heartbeat
- unusual bleeding or bruising
- yellowing of the skin or eyes
- difficulty breathing or swallowing